Setting the Standard in Flash Chromatography Performance

​Save Time, Save Space
  • Flow rates from 1 to 300 mL/min
  • Operating pressure up to 300 psi (20 bar)
  • Bigger touchscreen, 12 or 15 inches
  • Wider Dynamic Range UV Detector
  • Improved baseline correction supports use of absorbing solvents
  • Faster processing with streamlined user interface
Photo Diode Array ​Detection​
  • UV and UV-Vis detectors use PDA technology
  • Display spectra in real time or post-run
  • Collect based on purity indicators​
Internal Vapor Sensor
  • Automatically stop the system if vapors are detected (level is user-configurable) for safe operation
Mass Dire​cted Purification
  • Collect only those peaks matching the mass of your compound
  • Eliminate the need for further analysis—save time in post-purification processing​
Integrated ELSD to Collect Non-Ch​romophoric Non​-Volatile Compounds
  • Integrated into the CombiFlash: No additional system footprint
  • All parameters programmed based on the solvent used or optimize operating conditions for your separation
  • Offers scalability and sensitivity for a wide sample load range​
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Focus Gradi​​ent​ Generator

​​Improved Resolution is​ One Touch Away!

Save time and solvent while increasing col​umn loading. The Focus Gradient Generator for flash delivers optimized, predictive preparative method development using the results of a scouting run more quickly and efficiently than TLC. The Focus Gradient Generator in the CombiFlash® NextGen system makes calculations fas​​t and easy, eliminating the need to run multiple TLCs with different mobile phase concentrations. When combined with a PurIon™ mass spectrometer, you actually know which peak represents your compound of interest to optimize the method around — no guessing which spot is the target material.

Easy as 1, 2, 3​​​

graph with random peaks
Scouting ​Run
graph focused on peaks
Focused Run

Focus Gradient Generator paired with the PurIon mass spectrometer

Easy to Use Meth​​od Optimization Right the First Time!

No more guessing which peak is your compound! Coupling a scouting run with MS data means you can now have confidence that the separation is optimized for your target compound. Getting things done right the first time, saves money, solvent and most importantly time.​​​​

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Use of Focus Gradient Generator and PurIon MS to determine a purification method from a 4 g to a 40 g column.​​​​​
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​For a full list of product specifications, see the ​​​​​Data​​sheet​​.​​​​​​