​Powerful Mixing

Special grooves machined into the tops and sides of the mixer-inserts provide strong circulation and nearly instantaneous homogenization of cell contents. This system prevents the formation of regions of higher concentration of API under the membrane, thereby reducing test variability.​

Test Preparation

Phoenix cells are quick to set up. Dosage forms are applied to an easily accessible opening in the cell cap. No clamps are req​uired. Bubbles are easily detected and removed simply by lifting the cell and tipping it to one side.

Chemical Compatibility

The Phoenix press-on style of cell cap is made from polyether ether ketone (PEEK), sealed with O‑rings made from Viton™ (fluoroelastomer). The Phoenix threaded style of cell cap is made from polytetrafluoroethylene (PTFE), sealed with O-rings made from either Viton or Kalrez™ (perfluoroelastomer) for higher compatibility with aggressive solvents such as THF and DMSO.

Serialized Components​

As each diffusion cell, mixer, and cell cap has its own serial number, traceability and process control are improved.​​​

Bro​ad Range of Test Parameters

With three sizes of diffusion cells, short and tall mixer-inserts for each, and a variety of cell cap designs and sizes, the Phoenix platform provides analysts with a broad range of diffusion cell testing capabilities​. Receptor media volumes range from 10 mL to 30 mL, dosage volumes from 0.25 mL to 6.3 mL and orifice diameters 9 mm to 20 mm.

* Volumes shown are nominal; actual volumes will vary and are determined by measurement of each specific diffusion cell assembly in the lab.​​​​​​​​​​​​​​​​​​​​​​​​​

Receptor Media Volume Adjustment

Phoenix diffusion cells allow the analyst to adjust receptor media volume simply by changing the mixer-insert. The use of the short mixer-insert (13 mm height) provides the maximum available volume for a particular cell size. The tall mixer insert (30 mm height) provides a lesser volume while still allowing samples to be taken from the center of the main body of the cell as specified in USP <1724> Semisolid Drug Products—Performance Tests.

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* Volumes shown are nominal; actual volumes will vary and are determined by measurement of each specific diffusion cell assembly in the lab.​​

PEEK and ​PTFE Mixer-Insert Selection

​Cell Size		Mixer Height (mm)	Cell Volume* (mL)	Mixer  Material	Part Number
For Small Cells	​	13	​13	PEEK	59-207-122
				PTFE	59-207-140
		30	10	PEEK	59-207-123
				PTFE	59-207-141
Medium		13	21	PEEK	59-207-126
				PTFE	59-207-143
		30	15	PEEK	59-207-127
				PTFE	59-207-144
Large	​	13	30	PEEK	59-207-130
				PTFE	59-207-146
		​​30	20	PEEK	59-207-131
				PTFE​	59-207-147​​

​Threaded Cap Kit Components

 

​​All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane sold separately. Threaded caps accommodate 25 mm dia. membranes with thickness 0.1 mm to 3.0 mm.
PTFE = Polytetrafluoroethylene​​

Press-on Cap Kit Components - General Applications​​

 

All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane sold separately. Cell caps accommodate 25 mm diameter membranes with thickness 0.1 mm to 1.0 mm.
PEEK = Polyether ether ketone ​

Press-on Cap Kit ​Components - Skin Applications​

 

All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane not included. Cell caps accommodate membranes with thickness 0.1 mm to 3.0 mm.
PEEK = Polyether ether ketone​​​​​​​​​
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