​Powerful Mixing

Special grooves machined into the tops and sides of the mixer-inserts provide strong circulation and nearly instantaneous homogenization of cell contents. This system prevents the formation of regions of higher concentration of API under the membrane, thereby reducing test variability.​

Test Preparation

Phoenix cells are quick to set up. Dosage forms are applied to an easily accessible opening in the cell cap. No clamps are req​uired. Bubbles are easily detected and removed simply by lifting the cell and tipping it to one side.

Chemical Compatibility

The Phoenix press-on style of cell cap is made from polyether ether ketone (PEEK), sealed with O‑rings made from Viton™ (fluoroelastomer). The Phoenix threaded style of cell cap is made from polytetrafluoroethylene (PTFE), sealed with O-rings made from either Viton or Kalrez™ (perfluoroelastomer) for higher compatibility with aggressive solvents such as THF and DMSO.

Serialized Components​

As each diffusion cell, mixer, and cell cap has its own serial number, traceability and process control are improved.​​​

Bro​ad Range of Test Parameters

With three sizes of diffusion cells, short and tall mixer-inserts for each, and a variety of cell cap designs and sizes, the Phoenix platform provides analysts with a broad range of diffusion cell testing capabilities​. Receptor media volumes range from 10 mL to 30 mL, dosage volumes from 0.25 mL to 6.3 mL and orifice diameters 9 mm to 20 mm.

Diffusion Cell Size

Receptor Media Volume*

Orifice Diameters

Dosage Chamber Volumes*

Small​

10 mL

9 mm

0.25 mL to 2.0 mL

11.3 mm

13 mL

9 mm
11.3 mm

Medium

15 mL

11.3 mm

0.40 mL to 3.5 mL

15 mm

21 mL

11.3 mm
15 mm

Large

20 mL

15 mm

0.71 mL to 6.3 mL

20 mm

​30 mL

15 mm
20 mm

* Volumes shown are nominal; actual volumes will vary and are determined by measurement of each specific diffusion cell assembly in the lab.​​​​​​​​​​​​​​​​​​​​​​​​​

Receptor Media Volume Adjustment

Phoenix diffusion cells allow the analyst to adjust receptor media volume simply by changing the mixer-insert. The use of the short mixer-insert (13 mm height) provides the maximum available volume for a particular cell size. The tall mixer insert (30 mm height) provides a lesser volume while still allowing samples to be taken from the center of the main body of the cell as specified in USP <1724> Semisolid Drug Products—Performance Tests.

receptor media volume, same info as earlier table

* Volumes shown are nominal; actual volumes will vary and are determined by measurement of each specific diffusion cell assembly in the lab.​​

PEEK and ​PTFE Mixer-Insert Selection

​Cell Size

Mixer Height
(mm)

Cell Volume*
(mL)

Mixer 
Material

Part Number

For
Small
Cells

small 13mm mixer

13

13

PEEK

59-207-122

PTFE

59-207-140

small 30mm mixer

30

10

PEEK

59-207-123

PTFE

59-207-141

Medium

medium 13mm mixer

13

21

PEEK

59-207-126

PTFE

59-207-143

medium 30mm mixer

30

15

PEEK

59-207-127

PTFE

59-207-144

Large

large 13mm mixer

13

30

PEEK

59-207-130

PTFE

59-207-146

large 30mm mixer

​​30

20

PEEK

59-207-131

PTFE

59-207-147​​

​Threaded Cap Kit Components

threaded cap diagram, dosage cover, clamp ring, dosage chamber, cell cap, o ring  

Cell Size

Orifice
Diameter
(mm)

Membrane
Exposed Area
(mm2)

Dosage Chamber
Height
(mm)​

Maximum Dosage
Volume
(mL)

O-Ring
Material

Cell Cap Kit
Part Number

Small

9

64

​​​​​13​​

0.8

Viton

59-207-210

0.8

Kalrez

59-207-212

11.3

100

1.3

Viton

59-207-211

1.3

Kalrez

59-207-213

Medium

11.3

100

1.3

Viton

59-207-225

1.3

Kalrez

59-207-227

15

177

2.3

Viton

59-207-226

2.3

Kalrez

59-207-228

Large

15

177

2.3

Viton

59-207-240

2.3

Kalrez

59-207-242

​20

314

4.1

Viton

59-207-241

4.1

Kalrez

59-207-243

​​All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane sold separately. Threaded caps accommodate 25 mm dia. membranes with thickness 0.1 mm to 3.0 mm.
PTFE = Polytetrafluoroethylene​​


Press-on Cap Kit Components - General Applications​​

press on cap diagram, dosage cover, dosage chamber, cell cap, o ring 

Cell Size

Orifice
Diameter
(mm)

Membrane
Exposed Area
(mm2)

Dosage Chamber
Height
(mm)

Maximum Dosage
Volume
(mL)

Cell Cap Kit
Part Number​

Small

9

64

​4

0.25

59-207-201

​20

1.3

59-207-202

11.3

100

4​

0.40

59-207-203

​20

2.0

59-207-204

Medium

11.3

100

​4

0.40

59-207-215

20​

2.0

59-207-216

15

177

​4

0.71

59-207-217

​20

3.5

59-207-218

Large

15

177

4​

0.71

59-207-231

20​

3.5

59-207-232

​20

314

4​

1.26

59-207-233

​20​

6.3

59-207-234

All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane sold separately. Cell caps accommodate 25 mm diameter membranes with thickness 0.1 mm to 1.0 mm.
PEEK = Polyether ether ketone ​


Press-on Cap Kit ​Components - Skin Applications​

press on cap diagram, dosage cover, dosage chamber, cell cap, o ring 

Cell Size

​​Membrane
Diameter
(mm)

Orifice
Diameter
(mm)

Membrane
Exposed Area
(mm2)


Dosage Chamber
Height
(mm)

Maximum Dosage
Volume
(mL)

​​O-Ring
Material

Cell Cap Kit
Part Number

Small

​16

11.3

100

​​7

​0.7

​​​Viton

59-207-205

​Medium

​25

15

177

1.2

​59-207-221

​Large

​25

20

314

2.2

​59-207-235​

All dimensions and volumes are nominal. Maximum dosage volume is based on dosage chamber filled to capacity.
*Membrane not included. Cell caps accommodate membranes with thickness 0.1 mm to 3.0 mm.
PEEK = Polyether ether ketone​​​​​​​​​